解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Reliable data on the distribution of causes of death (COD) in a population are fundamental to good public health practice. In the absence of comprehensive medical certification of deaths, the only feasible way to collect essential mortality data is verbal autopsy (VA). The Tariff Method was developed by the ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0527-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:In July 2014, an outbreak of Ebola virus disease (EVD) started in Pujehun district, Sierra Leone. On January 10th, 2015, the district was the first to be declared Ebola-free by local authorities after 49 cases and a case fatality rate of 85.7%. The Pujehun outbreak represents a precious opportunity for impro...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0524-z
更新日期:2015-11-26 00:00:00
abstract::Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0522-1
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:Inappropriate treatment of non-malaria fevers with artemisinin-based combination therapies (ACTs) is a growing concern, particularly in light of emerging artemisinin resistance, but it is a behavior that has proven difficult to change. Pay for performance (P4P) programs have generated interest as a mechanism...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-015-0497-y
更新日期:2015-10-16 00:00:00
abstract::Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0508-z
更新日期:2015-10-16 00:00:00
abstract::In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0490-5
更新日期:2015-10-14 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer deaths globally. However, there is overwhelming evidence that a large proportion of CRC cases and deaths could be prevented by screening. Nevertheless, CRC screening programmes are offered in a minority of coun...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0498-x
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investi...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12916-015-0459-4
更新日期:2015-09-18 00:00:00
abstract:BACKGROUND:The ability to do online searches for health information has led to concerns that patients find the results confusing and that they often lead to expectations for treatments that have little supportive evidence. At the same time, the science of summarizing research evidence has advanced to the point where it...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0436-y
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Castration-resistant prostate cancer (CRPC) is associated with wide variations in survival. Recent studies of whole blood mRNA expression-based biomarkers strongly predicted survival but the genes used in these biomarker models were non-overlapping and their relationship was unknown. We developed a biomarker...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0442-0
更新日期:2015-08-21 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) elimination is being seriously considered globally. Current elimination models require a combination of highly effective HCV treatment and harm reduction, but high treatment costs make such strategies prohibitively expensive. Vaccines should play a key role in elimination but their be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0440-2
更新日期:2015-08-20 00:00:00
abstract::Breast cancer is the most common cause of cancer and cancer death worldwide. Although most patients present with localized breast cancer and may be rendered disease-free with local therapy, distant recurrence is common and is the primary cause of death from the disease. Adjuvant systemic therapies are effective in red...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0439-8
更新日期:2015-08-17 00:00:00
abstract:BACKGROUND:It is known that antimalarial drugs reduce the risk of low birth weight (LBW) in pregnant patients. However, a previous Cochrane review did not evaluate whether the level of antimalarial drug resistance could modify the protective effect of antimalarial drugs in this regard. In addition, no systematic review...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12916-015-0429-x
更新日期:2015-08-14 00:00:00
abstract:BACKGROUND:The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistently tyrosine-705 phosp...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0416-2
更新日期:2015-08-03 00:00:00
abstract:BACKGROUND:The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries. Previous predictions of these used only limited information on underlying vaccine properties and...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12916-015-0408-2
更新日期:2015-07-29 00:00:00
abstract::Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0384-6
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors. METHODS:Over half a million twin births of low risk pregnancies in the US, from 1995 to 2004, were used to cons...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0401-9
更新日期:2015-07-03 00:00:00
abstract:BACKGROUND:Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12916-015-0362-z
更新日期:2015-06-08 00:00:00
abstract::The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0359-7
更新日期:2015-05-14 00:00:00
abstract::The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...
journal_title:BMC medicine
pub_type: 评论,杂志文章
doi:10.1186/s12916-015-0344-1
更新日期:2015-05-09 00:00:00
abstract:BACKGROUND:Medical apps are widely available, increasingly used by patients and clinicians, and are being actively promoted for use in routine care. However, there is little systematic evidence exploring possible risks associated with apps intended for patient use. Because self-medication errors are a recognized source...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0314-7
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general popul...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0329-0
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0331-6
更新日期:2015-04-20 00:00:00
abstract::This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.Please see related article: http://www.biomedcentral.com/1741-7015/13/59. The statement in the competing interests should read as follows: This study is ...
journal_title:BMC medicine
pub_type: 已发布勘误
doi:10.1186/s12916-015-0338-z
更新日期:2015-04-16 00:00:00
abstract:BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0313-8
更新日期:2015-03-30 00:00:00
abstract::Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0296-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0302-y
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired...
journal_title:BMC medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12916-015-0290-y
更新日期:2015-03-11 00:00:00
abstract:BACKGROUND:Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to accurate differentiation of patients with higher and lower risk for mortality. This study explored th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0242-y
更新日期:2014-12-17 00:00:00
abstract::Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-014-0222-2
更新日期:2014-12-08 00:00:00
abstract:BACKGROUND:Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the im...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0183-5
更新日期:2014-10-16 00:00:00
abstract::Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhea that occurs in individuals exposed over time to poor sanitation and hygiene. It is implicated as a cause of stunting and malnutrition, oral vaccine failure and impaired development in children from low-income cou...
journal_title:BMC medicine
pub_type: 评论,杂志文章
doi:10.1186/s12916-014-0187-1
更新日期:2014-10-14 00:00:00
abstract:BACKGROUND:The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presen...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0164-8
更新日期:2014-09-30 00:00:00
abstract:BACKGROUND:Intimate partner violence is common among women having abortions, with between 6% and 22% reporting recent violence from an intimate partner. Concern about violence is a reason some pregnant women decide to terminate their pregnancies. Whether risk of violence decreases after having an abortion, remains unkn...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0144-z
更新日期:2014-09-29 00:00:00
abstract::The lack of formal training programs for peer reviewers places the scientific quality of biomedical publications at risk, as the introduction of 'hidden' bias may not be easily recognized by the reader. The exponential increase in the number of manuscripts submitted for publication worldwide, estimated in the millions...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0179-1
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since N...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0137-y
更新日期:2014-08-26 00:00:00
abstract::In this podcast, we talk to Dr Sunil Verma about the evolution of HER2 as a therapeutic target in breast cancer, and about how targeted therapy has revolutionized breast cancer treatment. We also discuss new agents in clinical development and the ways in which advances in treating HER2-positive breast cancer can be us...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-014-0129-y
更新日期:2014-08-12 00:00:00
abstract::The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some settings, and scores are increasingly being employed to define Mediterranean diet adherence in epidemiological st...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-112
更新日期:2014-07-24 00:00:00
abstract::The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-014-0124-3
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-101
更新日期:2014-06-18 00:00:00